Only in the beginning I struggled with the controls (and I didn't play the first AC so took me longer).
But after about 5 hours in I had the hang of it, then the only other issue were with the tombs and that 1 part when your'e the other character and climbing that building.
Honestly it's my game of the year, I have very little to complain about with it, enjoyed it from start to finish, all 30 hours of it.
I platinum'd Uncharted 2, so I guess you could say I played it a lil bit
Uncharted 2 is a really top game that is really polished.
But it is a bit linear, always the same path from start to finish. That's where I like AC2 over it mostly, just the sheer depth of it all and playing bit more at your own pace and discovering the world at your pace.