Yes and no. Penrith, like Cronulla and Manly, has a very geographically concentrated fan base, so moving any games away from their home game is risky. For clubs like Souths, Bulldogs, Dragons, Eels (and even the Wests Tigers and Roosters), their fan bases have often spread across the city, so moving a game away from their 'home' is less risky, and if it's the right game, with the right opponent, offers a lot of upside.
The balancing act is working out which games are worth moving, ensuring they take place at an appropriate timeslot and the right investment in marketing and transport is put in place.