I played around with the N64, but because so many of the games rely on analogue sticks I found it not worth the effort. The best games on the system are just not as fun with digital sticks.
So I ended up with Mame, Sega Naomi games (very good, made Sega Rally and Daytona play well with a joysticks, even Virtua Cop plays amazing using a joystick), Daphe laser disc games, Gameboy Advance, SNES and Genesis.
Had a go with C64 and Amiga, but it really wasn't worth the effort required to setup each game, as I would need to use save states and load those to get the arcade effect I want. Too many silly keyboard or something else required at inopportune times.