Hopefully Dembele isn't out for any amount of games, he's crucial at the moment. Defoe looked better then Ade (not saying much) and will be the starter for the big games from now on I'd say.
You never know with Defoe, he could get hot and go on a scoring run, like he did at the start of the year when he was carrying us. But he could also go on a barren run like he was before he got injured.
Will be interesting to see what team we put out against Inter, we have a massive game at Liverpool a few days after and I think we should play some of our reserves.
Give Dembele a rest, regardless of his injury, and I'd also take out Walker, Ade, and possibly Parker too. Dare I say it, we may also need to rest Bale for a game soon....
Good thing is we have a bit of decent depth this year with players like Dempsey Sig Holtby.