After you make a line break, start running in a diagonal line towards the sideline and the computer defender will often not be able to make any ground on you. Great for scoring length of the field tries.
Always run at the wingers on kick off returns. Plenty of length of the field tries to be had.
If you have a fast player in your team, it's very easy to run sideways and get around the entire defensive line for a big bust.
On the 5th tackle, just spread the ball wide and you'll score almost every time as the computer wingers drop back waiting for a kick and don't react to you making a break until it's too late. You can often score tries in front of the wingers while they wait back on the dead ball line. :lol:
As someone else said, put your fastest player at halfback.
Put a good defender at fullback. Even if he's slow, Corey Pearson doesn't go too badly. :lol:
Choose the fastest player possible in every position.
Run at diagonals when trying to break tackles.
That's all I can think of at the moment. Once you work out the games bizarre AI quirks, it quite easy to put 40-50 points on in most games on legend(15 min games) I've found that every team plays the same way and the only reason I ever lose is through AI glitches.