As someone who has played Fallout 3 only and even then sparingly, I found the first 2 or 3 hours daunting.
Normally would play this kind of game on PC but I don't think my PC could do justice to it, so picked it up on Xbone.
Have had some difficulty in getting used to shooting/aiming with the controller and got absolutely annihilated by the Deathclaw in my power armour suit. Dropped it from normal back to very easy and will work my way back up.
Did a bit of exploring, some of the base quests with the base building stuff for Sturges and some of the other quests to help out one other settlement (which I'm thinking about putting my base at).
Still not 100% what to do with the base building stuff, I remember having a mod in Skyrim that gave me a treehouse as a base. Same kinda thing? I always used to log out when in the treehouse, probably hang over from logging out in Inns in WoW for the exp bonus.
The graphics are stunning (although some of the night scenes seem a bit dark) and it so far has drawn me in far more than Witcher 3 ever did. The world is really cool and love the dog!