Well we're close to getting our best possible backline, with the only changes IMO being:
When James Roberts is fit, move Lewis Brown back to the second row. Drop Clint Newton.
When Josh Mansour is fit, drop David Simmons (even though he was good, Travis Robinson is worth sticking with. He has his flaws, but he is also only 3 games into his NRL career and has plenty of room for improvement)
No room for Brad Tighe. So I wouldn't bother making a change to our backline until the above players are ready.
Our halves this year are a lost cause. Walsh had a good game last night, but only ever seems to be able to produce them against the absolute worst teams. Which is why the last 2 years his best games have been against the Eels. Great team to save his best for though.

Throw in longterm injuries to Coote and now Austin. We don't even have room to tinker with them anymore.
Forward pack... Kingston has to go IMO. Start Segayaro and use Brown at hooker when he needs a break. Give us a bench with 2 front rowers and 2 second rowers. With the second rowers having more utility value then having Kingston in the team anyway. Ideally at full strength we can rotate McKendry, Grant, Latimore and Masoe in the front row. With Brown, Manu, Docker/Plum starting in our second row, and having 2 of Robinson, Cherrington, VTK, Austin etc. on the bench.
If Tighe came back and Brown moved to the second row at the expense of Newton I wouldn't be upset. But I'd then be worried that Roberts would be stuck waiting ages for a run like Moylan and Robinson were.