Think I'm about 36 hours in, have done a bit of all three major quest lines so far. Brotherhood are a hell of a lot of fun, having Danse as a companion with his fire-power is quite useful. Minutemen quests are a little repetitive tbh. Currently partway through clearing some settlement near the water. Main quest is probably the most engrossing thus far. I'm up to the mission where you have to kill a Courser. Gonna leave that for a bit, level up, f**k about with some weapons mods etc.
Might pay attention to some settlements too...I've given everyone a bed, food, water, defence and f**k all else.