Panthers coach Ivan Cleary has named his side to face Gold Coast Titans at Cbus Super Stadium on Sunday.
The Panthers will field a new-look spine and their least experienced line-up of the season, with Dylan Edwards (hamstring), Dean Whare (thigh) and Apisai Koroisau (elbow) sidelined through injury.
The trio joins Zane Tetevano, Kurt Capewell, Brian To'o and Jed Cartwright in the club's rehabilitation crew.
Caleb Aekins returns at fullback, Mitch Kenny has been handed his first starting role for 2020 and winger Malakai Watene-Zelezniak makes his first NRL appearance since Round 8 last year.
The club has again received an exemption from the NRL to select Lindsay Smith on the extended bench, where he is joined by development players Pat Hollis and Daine Laurie.
The Panthers will wear the pink 2020 Alternate Jersey.
1. Caleb AEKINS - sponsored by
CC Tyres Penrith
2. Josh MANSOUR - sponsored by
MKJ Projects
3. Brent NADEN - sponsored by
Potter Automotive
4. Stephen CRICHTON - sponsored by
Penrith Toyota
5. Malakai WATENE-ZELEZNIAK - sponsored by
Soneta Plumbing
6. Jarome LUAI - sponsored by
Hertz
7. Nathan CLEARY - sponsored by
Chemtools
8. James TAMOU (c) - sponsored by
Protech Locksmiths
9. Mitch KENNY - sponsored by
Cetnaj Wetherill Park
10. James FISHER-HARRIS - sponsored by
Chardon & Abbott Home Loans
11. Viliame KIKAU - sponsored by
Hix Group
12. Liam MARTIN - sponsored by
AMA Event Management
13. Isaah YEO - sponsored by
Casella Express
14. Tyrone MAY - sponsored by
Signace
15. Spencer LENIU - sponsored by
Wisdom Dental and Denture Clinic
16. Moses LEOTA - sponsored by
Fornari's Interior Linings
17. Billy BURNS - sponsored by
Wright Way Plumbing & Civil
18. Matt BURTON - sponsored by
Stylus Blinds
19. Daine LAURIE - sponsored by
Southlands Estate Agents
20. Lindsay SMITH - sponsored by OAK Plus
21. Pat HOLLIS - sponsored by
Brightside Music