Doug Flutie lays claim to perhaps the greatest Collegiate play of all-time (search on youtube.com) and came to Buffalo after a successful stint in the CFL (Jeff Garcia followed a similar path to San Fran).
I was a closet fan of Flutie, I liked watching him play.
Just speaking of San Diego, three players I would like to mention from that would be classed as some of my favourites include; Stan Humphries, LT and Natrone Means.
Humphries was a backup QB in Washington and won the SD job and didn't relinquish it until he retired. He led the Chargers to the 1994 Super Bowl only to be dismantled by Young and Rice.
Stan's spiral was ugly, he cared little about self preservation or his stats - he cared only about winning and had a hellova winning % when he left the NFL (though perhaps diminished a little in his last couple of seasons).
Tomlinson is going to challenge any RB as the greatest of all-time. A freak. The NFL's best player.
Natrone Means was a big, bruising back in the Bettis mould. He could have had a great career though from what I read/hear, his attitude wasn't great and his weight was up and down like a yo-yo.
Had a couple of really good seasons, highlighted by the Super Bowl run with Humphries, though his career stalled and ground to a halt at the Jags from memory. I liked him though. He was a big back with attitude.