"Seizures have been reported in patients receiving tramadol within the recommended dosage range. Spontaneous post-marketing reports indicate that seizure risk is increased with doses of tramadol above the recommended range. Concomitant use of tramadol increases the seizure risk in patients taking:
•Selective serotonin re-uptake inhibitors (SSRI antidepressants or anorectics),•Tricyclic antidepressants (TCAs), and other tricyclic compounds (e.g., cyclobenzaprine, promethazine, etc.), or•Other opioids. Administration of tramadol may enhance the seizure risk in patients taking:
•MAO inhibitors (see also
WARNINGS, Use with MAO Inhibitors and Serotonin Re-uptake Inhibitors),•Neuroleptics, or•Other drugs that reduce the seizure threshold. Risk of convulsions may also increase in patients with epilepsy, those with a history of seizures, or in patients with a recognized risk for seizure (such as head trauma, metabolic disorders, alcohol and drug withdrawal, CNS infections). In tramadol overdose, naloxone administration may increase the risk of seizure."
http://www.drugs.com/pro/tramadol-er.html
A bit of a read albeit educational.
And if anyone here is not familiar to seeing a patient in a coma.Think of someone on a bed,bloated to half the size they usually are with a constant sweat all over them with connections to the machines all over the place.
It is a very surreal scene to which I've witnessed many times,which few survive.
