You do see some trick plays when teams are desperate, partic. when they receive a kick off and there is no time for another play. If you watch College football, there are a number of teams that play the triple option, which is essentially similar to a RL halfback running down a blind side with a centre/2nd rower on his outside, and having the choice to keep it, lateral to the runner or peg it downfield. It works (sometimes) in College because there is typically not enough quality in depth in the defenses. In the NFL, the defenses are too fast and you would just get smashed.
It's not as if the coaches don't spend hours and hours trying to devise plays that will work. You gotta remember that NFL defenders are allowed to contact attackers who don't have the ball in many circumstances....which makes plays involving laterals a lot harder.
