Couple of Brisbane Broncos players that spring to mind.
Obviously Jharal Yow Yeh had a long career ahead of him before the freak accident at WA. That was one of those injuries that was so rough it really puts a dent in your appreciation for the game. That injury was only compounded further when a future first grader by the name of Matt Berwick was involved in a car accident that completely ruined his career while the other bright prospect in Jerome Leedy couldn't stay on the field long enough to play 20s. Factor in Kahu's run of injuries, Whitchurch needing spinal surgery and the Gagai drama and it's pretty clear why the Broncos had to stick with Maranta for the majority of 2013.
I think fans often forget that Steve Michaels was a very handy centre/winger in his day before Nigel Vangana twisted him in a tackle and he suffered this horrific knee injury that robbed him of his speed. Before then, he was every bit as good if not more so than Darius.
A blast from the past would be Danny Bampton - played first grade as an 18 year old in one of the greatest Rugby League teams of all time in that 1998 squad and had everything you'd want out of a modern centre except for a clean bill of health.
I reckon Hodges would be ranked right up there with Meninga and Inglis as one of the best backs to play the game had he not blown his knee in Origin I 2003. Watching some of the footage of him back in the day is just freakish.
